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Originally studied because of their role in inflammation, chemokines and their receptors are now known to play a crucial part in directing the movement of mononuclear cells throughout the body, engendering the adaptive immune response and contributing to the pathogenesis of a variety of diseases. The interaction of chemokines, their receptors, growth factors, inflammatory with cancer cells forms a complex network at the tumour site, responsible for the overall progression or rejection of the tumour. In the malignancy context, chemokines play diverse effects, most of them deriving from their ability to induce cell migration.
created March 14, 2011
updated March 14, 2011